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These tails are topic to a number of publish-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).

The exception to the rule is the DOT1 family, members of which methylate K79 in the globular area of histone H3 and that are structurally not associated to SET-domain proteins 4 - 6 Current work suggests that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later)