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These tails are topic to a number of publish-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).
meredithconnell.co.nzRepeat this step thrice to make sure higher coupling of the primary activated amino acid. It has utilized its core platform technologies to allow it to develop a powerful early discovery pipeline focussed on the lysine methyltransferase (KMTS) class of targets.
The exception to the rule is the DOT1 household, members of which methylate K79 within the globular region of histone H3 and which are structurally not related to SET-area proteins 4 - 6 Latest work suggests that SET-area-containing proteins methylate a few proteins in addition to histones (see later)
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