Though the flavour of this essay in relation to dieting is quite detrimental, it will be imprudent to counsel that all dieters battling the cravings and emotional consequences of dieting, ought to forthwith reject their diets.

Whereas I used to purchase into this wholeheartedly, just lately I am not so convinced of the physiological advantages, but I do suppose that psychologically, this approach (also known as non-linear dieting) will be extraordinarily useful.

The exception to the rule is the DOT1 family, members of which methylate K79 in the globular area of histone H3 and that are structurally not associated to SET-area proteins four - 6 Recent work suggests that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later)